// RIGOR-PRS-Secure++
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Technical Specification: RIGOR-PRS-Secure++

Post-Quantum Genomic Evidence Generation Architecture

The RIGOR-PRS-Secure++ algorithm represents a forward-looking solution engineered to address a critical challenge at the intersection of genomics and cybersecurity. By integrating a new generation of post-quantum cryptographic primitives into a multi-stage processing pipeline, the algorithm provides end-to-end protection for the generation of polygenic risk scores.

Kyber-768 KEM Dilithium-III Sig GRCh38 Alignment

Pipeline Execution

Modular Operational Phases

  • Phase 0: Initialize PQC Environment

    Establishes foundational Kyber-768 keys and secure TLS channels.

  • Phase 1: Secure Data Ingestion

    Client-side hybrid encryption of raw VCF data using AES-256-GCM encapsulated by Kyber.

  • Phase 2: PQC-Secured Annotation

    Secure API queries to external databases over PQC-TLS channels.

  • Phase 3: Encrypted Model Processing

    PRS computation within hardware-secured Trusted Execution Environments (TEE).

  • Phase 4: Final Ledger Commitment

    Immutable blockchain-verified audit trail generation.

FIG. 2: QRDE-AEAD Flowchart

Dual-Envelope Authenticated Encryption

Raw Genomic Payload (VCF)
Kyber-768 KEM (Key Encapsulation)
AES-256-GCM (Inner Envelope)
HMAC-SHA3-256 (Outer Envelope)
Final Encrypted Package

> Status: Waiting for input...

Cryptographic Primitives

NIST Finalized Standards Implementation

Primitive Algorithm Security Level Application
KEM Kyber-768 NIST Level 3 Secure Key Exchange / TLS
Digital Signature Dilithium-III NIST Level 2 Authenticity / Ledger Signing
Symmetric Cipher AES-256-GCM Standard Bulk Data Encryption
Hash Function SHA3-256 Standard Integrity Checks / MAC